Zebra
Zebra ZD421 4-Inch Direct Thermal Desktop Label Printer, USB, Bluetooth | ZD4A042-D01M00EZ
Zebra ZD421 4-Inch Direct Thermal Desktop Label Printer, USB, Bluetooth | ZD4A042-D01M00EZ
SKU:ZD4A042-D01M00EZ
Zebra Part Number ZD4A042-D01M00EZ
Zebra, ZD421, 4" Direct Thermal Label Printer
Quick Answer: The Zebra, ZD421, 4" Direct Thermal Label Printer is a label printer identified by manufacturer SKU ZD4A042-D01M00EZ. It is best for buyers who need this exact configuration and want source-supported product details, compatibility guidance and purchasing support before ordering.

Key Features and Product Details
- The ZD421 offers new, advanced features that make it stand apart.
- It includes a new, more intuitive user interface, powerful architecture and field-upgradeable wireless kit.
- It also has new media guide and media handling designs that make daily operation even easier.
- Features: Direct Thermal 203 DPI USB and Bluetooth Interface 4" Print Width USB cable included Modular Connectivity Slot Spec Sheet
Best Use Cases
This product is a strong fit for businesses replacing an existing unit, standardizing a deployment, expanding a partner-approved POS configuration, or ordering a specific manufacturer part number. Common environments may include retail counters, restaurants, warehouses, offices, healthcare operations and other commercial workflows, depending on the product configuration.
Compatibility and Configuration
Compatibility depends on your POS software, operating system, connection type, drivers, accessories, and configuration. Confirm compatibility before ordering.
Match the complete SKU ZD4A042-D01M00EZ, interface, power requirements, regional configuration and included accessories against your current system. Similar model names can represent different interfaces, colors, power supplies, warranties or regional versions.
Why Buy from ShopPOSPortals
ShopPOSPortals helps businesses source partner-focused POS hardware and related technology by exact brand, model and SKU. Use the product images and part number on this page to verify the configuration, and contact the team when you need help comparing compatible options or related accessories.
Related Products
Frequently Asked Questions
What is the SKU for this product?
The manufacturer or catalog SKU shown for this configuration is ZD4A042-D01M00EZ.
Is this product compatible with my POS system?
Compatibility depends on the software, operating system, interface, drivers, accessories and configuration in use. Confirm the exact requirements before ordering.
Does the image guarantee every included accessory?
No. Product images can show optional or representative accessories. Confirm the written configuration and included items for SKU ZD4A042-D01M00EZ.
Can ShopPOSPortals help verify the correct configuration?
Yes. Send the current model, required interface, software platform and any accessory requirements so the team can help confirm the appropriate part number.
Bottom Line
Choose the Zebra, ZD421, 4" Direct Thermal Label Printer when you need the exact Zebra ZD4A042-D01M00EZ configuration. Verify compatibility and included accessories before ordering to avoid selecting a similar-looking but different model.
Zebra ZD421 (USB and Bluetooth) for pharmacy labeling
Specifications
| Model | Zebra ZD421 |
|---|---|
| Print method | Direct thermal (no ribbon) |
| Resolution | 203 dpi (8 dots per mm) |
| Maximum print width | 4.09 in. (104 mm) |
| Media width | 0.585 in. to 4.25 in. (15 mm to 108 mm), 1 in. core rolls |
| Interfaces | USB 2.0, USB Host, Bluetooth Low Energy; modular slot for optional Ethernet, Wi-Fi or serial |
| Printer languages | ZPL II, EPL 2, XML, ZBI, PDF Direct |
| Size and weight | 8.69 in. L x 6.98 in. W x 5.93 in. H, 2.98 lb (1.35 kg) |
Pharmacy use cases
Combined prescription label strips, delivery and will-call labels, and shelf labels from one workstation.
Replacement guidance
Zebra names the ZD421 as the replacement for the ZD420 and GK420 series, and its trade-up guide also lists it for the LP 2844 and TLP 2844. It uses the same 4-inch media and the ZPL and EPL languages of those printers, and Zebra offers a mounting adapter bracket so the ZD400 series fits the GK420 and LP/TLP 2824 footprint. For GC420 printers Zebra names the ZD200 series (ZD220); for GX420 and GX420Rx printers Zebra names the ZD621.
Labels and media
1 inch core direct thermal rolls up to 4.25 inches wide, for example 4 x 2 inch labels.
Pharmacy questions
Can several workstations share this printer?
Not over the network as supplied. Choose the USB, Ethernet and Bluetooth model for a shared printer.
Complete the pharmacy workstation: Zebra DS9308 hands-free scanner · Citizen CT-S310II receipt printer · Star CD4 cash drawer · labels & supplies · replacement pharmacy printers · all pharmacy equipment · pharmacy hardware guide
Compatibility with your pharmacy software and label format should be verified before ordering. Need equipment for multiple pharmacy locations? Ask about volume pricing, staging and rollout support. Not sure which printer you need? Send us your current printer model, label size and pharmacy software.
